Protein refolding is a process of
recovering protein aggregates in inclusion bodies in the form of misfolded and
inactive proteins expressed by prokaryotes such as Escherichia coli back into
proteins with correct conformation and bioactivity under appropriate conditions
in vitro. It is a key technology for biopharmaceutical companies but a major
bottleneck in protein production in prokaryotic expression systems. Leto Labs,
having been specializing in protein refolding for many years, has a core team
with over ten years’ experience in this technology and rich experience in its
industrialization. Our team is summarizing the experience to form an
independent technological system of ours.